产品货号：
LA10360
中文名称：
重组人TNFRSF1A
英文名称：
TNF Receptor Type I,recombinant
产品规格：
10μg
发货周期：
1～3天
产品价格：
询价
TNF Receptor Type I,is also known as TNF R-p55/p60 and TNFRSF1A.It is a type I transmembraneprotein member of the TNF receptor superfamily.It is expressed in most cell types.Binding of eitherTNF-α or TNF-β to TNF-R1 initiates a signal transduction pathway that results in the activation of thetranscription factor NF-κB,whose target genes are involved in the regulation of inflammatory responses,and,in certain cells,induce apoptosis.TNF-R1 is essential for proper development of lymph nodegerminal centers and Peyer’s patches and for combating intracellular pathogens such as Listeria.It isstored in the Golgi and translocates to the cell surface following proinflammatory stimuli.
| 别名 | Soluble Tumor Necrosis Factor type I,TNFRSF1A,TNFAR,TNF-R55,TNFR60,p55,CD120a |
| 种属 | Human |
| 来源 | CHO |
| 分子量 | 28～35kDa,observed by reducing SDS-PAGE. |
| 纯度 | > 95% as analyzed by SDS-PAGE. |
| 供货形式 | Lyophilized after extensive dialysis against PBS. |
| 复溶 | Reconstituted in ddH2O or PBS at 100μg/ml. |
| 内毒素 | <0.2 EU/μg,determined by LAL method. |
氨基酸序列：
DSVCPQGKYI HPQNNSICCT KCHKGTYLYN DCPGPGQDTD
CRECESGSFT ASENHLRHCL SCSKCRKEMG QVEISSCTVD
RDTVCGCRKN QYRHYWSENL FQCFNCSLCL NGTVHLSCQE
KQNTVCTCHA GFFLRENECV SCSNCKKSLE CTKLCLPQIE
N
Lyophilized recombinant Human TNF Receptor Type I remains stable up to 6 months at lower than -70℃ from date of receipt.Upon reconstitution,Human TNF Receptor Type I should be stable up to 1 week at 4℃ or up to 2 months at -20℃.
ED50 <50ng/ml,measured in a cell proliferation assay using 929 cells in the presence of 1ng/ml human TNF-α.
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